Zilisch karted primarily in the United States until 2017 when he won the Mini Rok World Championship in South Garda, Italy competing against more than 160 other competitors from 33 different countries.

Zilisch also competed in the Mazda MX-5 Cup Shootout competition, in late 2021, winning the $110,000 scholarship which would fund his participation in the series in 2022.

In late 2021 Zilisch also ran his first Trans Am TA2 race at Virginia International Raceway earning pole position while shattering the track record as a rookie driver.

On March 18, 2024, it was announced that Zilisch would return to Pinnacle Racing Group to run a full season in the ARCA Menards Series East, driving the No.

[6] In his first start at Five Flags Speedway, he missed practice and qualifying due to being at Circuit of the Americas for the NASCAR Truck Series race, and was replaced by Luke Fenhaus.

In his next race at Dover Motor Speedway, Zilisch took advantage of the leader's mishaps and led the final 42 laps of the event to earn his first career win in both the main and East Series.

[8] At the Nashville Fairgrounds Speedway, Zilisch qualified fourth and ran in the top three throughout the event, but did not have the car to beat the eventual race winner William Sawalich, he finished third behind Isabella Robusto.

[9][10] He continued with a hot streak of victories, winning the next two East Series events at Iowa Speedway and Lucas Oil Indianapolis Raceway Park, both in dominating fashion.

[11][12] At Michigan, his first start on an intermediate racetrack, Zilisch passed Tanner Gray late in the event and held off a charging Andrés Pérez de Lara in the final laps to score another victory, continuing his winning streak of 4–4 in the ARCA Series.

[14] On March 15, 2024, it was announced that Zilisch would run a three-race schedule for Spire Motorsports in the NASCAR Craftsman Truck Series, driving the No.

[15] He made his debut at Circuit of the Americas, shocking the field after winning the pole in his first career start, with a lap of 2:11.983, and a speed of 93.012 mph (149.688 km/h), seven tenths faster than the second-place driver of Corey Heim and was also the track record.

[16] On the first lap, Zilisch locked up his brakes and ultimately missed the first corner, losing the lead and falling to the back.

[19] On March 12, 2024, it was announced that Zilisch would run a four-race slate with JR Motorsports in the NASCAR Xfinity Series, driving the No.

[20] Following his 18th birthday on July 22, Zilisch will compete in the races at Watkins Glen, Kansas, Homestead–Miami, and the season finale at Phoenix.

[21] At Watkins Glen, Zilisch won the pole, led the most laps, and saved enough fuel in two overtime restarts for the win in his Xfinity Series debut, becoming the first driver in over three years (Ty Gibbs at the 2021 Daytona RC race) to win in their Xfinity Series debut.

[23] On December 12, 2024, it was announced that Zilisch will drive a Corvette Z06 GT3.R in the GTD Pro class in the 2025 Rolex 24 At Daytona alongside Shane van Gisbergen, Ben Keating and Scott McLaughlin in a joint partnership between Trackhouse Racing and TF Sport.

[28] Kerr was named the Southeastern Conference H. Boyd McWhorter Scholar-Athlete of the Year in 1990, one of only four Florida Gators to have won the award.