Conrad was a son of the Magdeburg Burggrave Burchard II of Querfurt and Matilda of Gleichen, a daughter of Count Lambert I zu Tonna.
Conrad attended the Cathedral School in Hildesheim and later studied with Lothar of Segni in Paris, who later became Pope Innocent III.
On the Sicilian expedition of Henry VI in 1194, the Chancellor Sigelo had died and Conrad, once one of the educators of the Emperor, was appointed as his successor.
A letter Conrad wrote describing the wonders of southern Italy, including classical ruins and volcanoes, survives because it was copied into the Chronicle of Arnold of Lübeck.
Before leaving, Conrad was involved in the transformation of the hospital cooperative in the camp of Acre on 5 March 1198, into the Teutonic Order.