Set in a dystopian future, and taking place several months after the events of the previous game, players again take on the role of series protagonist Nick Delios, a special government agent framed for attempted murder, and uncover a massive conspiracy that could threaten humanity.

In Conspiracies II, players take control of protagonist Nick Delios and can navigate 3D environments in first-person, search for clues, and use inventory items, some of which can be taken apart or combined with others, thus making up the majority of the game's puzzles.

[1] In addition, Lethal Networks incorporates action game elements, such as the character climbing and crouching, as well as physics-based pushing or pulling of large objects and vehicle driving.

[3] Earth has recently joined a conglomerate body of alien governments known as the Peripheral Galactic Alliance, expecting a significant improvement of its dystopian situation.

Delios soon finds himself entangled in another intergalactic conspiracy, after he is framed for the attempted murder of his ex-fiancé Annita Argyriou, the sister of the corporate tyrant Dimitris, and current president of the powerful company Detronics S.A. During his quest to clear his name, Delios uncovers multiple conspiracy networks, hidden agendas, lies and corruption throughout the Peripheral Galactic Alliance, which threaten the fate of entire universe.