Constance Friess Holman (February 11, 1908 – July 23, 1999) was an American physician and civil rights activist.

Publisher Adolph Ochs loaned her the money to attend medical school, because she had tutored his grandchildren during college; he forgave the debt when he died.

She taught clinical medicine at Weill Cornell, and she ran a drug treatment program.

[9][10] She gave an oral history interview to the Georgia O'Keeffe Museum Archives about their friendship.

Her first husband was surgeon William Alexander Cooper; they married in 1936, had two children, Jane and Peter, and divorced in 1969.