Constantine of Hessen-Rotenburg (May 24, 1716 in Rotenburg – December 30, 1778 in Schloss Blumenstein (Wildeck)) was Landgrave of Hesse-Rotenburg from 1749 until his death.

Born into the House of Hesse, cadet line of an ancient House of Brabant, Constantine was the son of Landgrave Ernest Leopold, Landgrave of Hesse-Rotenburg and his wife, Princess Eleonore of Löwenstein-Wertheim-Rochefort.

He had 8 children from his first marriage, including : When his first wife died in 1773, on 17 May 1775 he remarried with the French Countess Johanna Henriette de Bombelles (1751-1822), younger sister of Marc Marie, Marquis de Bombelles.

As her family didn't belong to the small circle of reigning of former reigning families, their marriage was treated as morganatic and upon marriage she received the title of Countess von Reichenberg.

Landgrave Constantin died on 30 December 1778 in Schloss Blumenstein in Wildeck, at the age of 62.