In 1465, together with his uncle, the Georgian king George VIII, Constantine was taken prisoner by the rebel prince Qvarqvare II Jaqeli, atabeg of Samtskhe (principality in southern Georgia).

In the winter of 1488, the Ak Koyunlu Turkomans led by Sufi Khalil Beg Mawsilu attacked Georgia’s capital Tbilisi, and took the city after a long-lasted siege in February 1489.

Thus, by the end of the 15th century, Georgia was divided into three independent kingdoms (Kartli, Kakheti, and Imereti) and five autonomous principalities (Samtskhe, Mingrelia, Guria, Abkhazia, and Svaneti).

Between 1492-1496, Constantine attempted to win an international support to reunite the country and defend it against the increasingly aggressive Muslim empires of Ottoman Turkey and Safavid Iran.

At the same time, the Iranian Safavids, led by the emerging king (shah) Ismail I were tempted to loot the feudal state, if only to distract himself from his main quarry; Shirvan.