She wrote and directed Dalagang Luksa (1939), where her own sister, Maria Clara Ruiz, played the title role of a woman who falls for a married man.
Consuelo and Salvador Osorio collaborated as directors and screenwriters on a number of films: Dolores (1939), starring Norma Blancaflor and her brother Jose Padilla Jr., Hindi Ko Akalain (1939), Tanikala ng Langit (1940), and Pagsuyo (1941).
[1] She directed a number of films for Premiere Productions, many of which were hits at the box office, starting with Bakya Mo Neneg (1947) starring Rosa del Rosario and Leopoldo Salcedo.
For Premiere, she also directed Halik sa Bandila (1948), a war film, Bagong Sinderella (1947), Pangarap Ko’y Ikaw Rin (1947), Bulalaka (1948), Maliit Lamang ang Daigdig (1948), Anak ng Panday (1949), Magkapilas na Langit (1949), Hiwaga ng Tulay na Bato (1950), Gulong ng Palad (1950), based on a popular radio soap opera, and Labis na Pagtitipid (1951).
Drakulita (1969) was a film about a vampire scare and used slapstick humor to highlight social issues, including having a trans woman played by German Moreno cope with her homophobic stepfather.