The Government of Hamburg counts the promotion of the then Vice-Consul John Parish to the rank of a consul in 1793 as the establishment of the first mission.

[2] I do hereby pray and request the Governors, Burgomasters and Senate of the Imperial free City Hamburgh, to permit the said John Parish fully and peaceably to enjoy and exercise the said Office (Vice Consul), without giving or suffering to be given unto him any Molestation or Trouble, but on the contrary to afford him all the proper Countenance and Assistance; I offering to do the same for all those who in like manner be recommended to me by the said Governors, Burgomasters and Senate of the Imperial free City Hamburgh.The first American mission to Hamburg was established in 1790 and John Parish was named Vice Consul.

[5] The new location of the Consulate General is at Kehrweider 8, 20257 Hamburg, in Amundsen Haus of the Hanseatic Trade Center building complex.

[10] In 1882, the larger one of the two houses was built, and in 1893 the smaller building was finished by architect Martin Haller, who also designed the Hamburg Rathaus.

[11] In the late 1990s portions of what used to be a larger property belonging to and surrounding the Consulate were sold off to raise needed cash for the U.S. Embassy in Berlin.

[5] In July 2022, the U.S. Consulate General moved its operations to leased office space in the Amundsen Hall building of the Hanseatic Trade Center, at Kehrwieder 8.