The Convent of San Francisco (historically known in Spanish as the 'Convento Grande de San Francisco') is located at the western end of Madero Street in the historic center of Mexico City, near the Torre Latinoamericana and is all that remains of the church and monastery complex.

This complex was the headquarters of the first twelve Franciscan friars headed by Martín de Valencia who came to Mexico after receiving the first authorization from the Pope to evangelize in New Spain.

At its peak, the church and monastery covered the blocks now bordered by Bolivar, Madero, Eje Central and Venustiano Carranza Streets,[2] for a total area of 32,224 square metres (3.2 ha; 8.0 acres).

In 1692, the Count of Galve and his wife were granted refuge there due to a large-scale rebellion in the city.

The end of the Mexican War of Independence was celebrated with a Te Deum at the monastery as the Trigarante Army of 16,000 troops marched past on Madero Street headed by Agustín de Iturbide.

Other parts of the old building are now a Methodist church facing Gante Street and a Panadería Ideal bakery.

Only the walls of the original De Profundis Room remain, the rest is remodeled into a bakery.