The hospital formerly served as a clinical campus of Robert Wood Johnson Medical School and the University of Medicine and Dentistry of New Jersey.

[3] Cooper is affiliated with the Coriell Institute for Medical Research and is a tertiary partner for 21 regional hospitals in the Delaware Valley.

The original hospital had 30 beds and provided health care services to the low-income population of Camden, New Jersey.

[10] The center offers patients in the Delaware Valley access to MD Anderson's cancer treatment protocols and clinical trials.

The MD Anderson Cancer unit at Cooper has 30 inpatient state-of-the-art private rooms on the fifth floor of the Roberts Pavilion.

[4] As of 2017, Cooper is one of the largest healthcare providers in the Philadelphia and South Jersey region with over 1.2 million outpatient visits annually and over 7,000 employees.