Cootes Store is an unincorporated community in Rockingham County, Virginia, United States.

Located in the Shenandoah Valley, it is situated north of Harrisonburg, south of Bergton, and west of Timberville.

The border with West Virginia is nearby, as is the edge of George Washington National Forest.

In 1870, merchants began using the Shenandoah River from Brock's Gap to Cootes Store for transporting people and goods.

At worst, the water was four feet deep and washed away many barns, cottages and other features in the area.