The Copa América Centenario qualifying play-offs were the international football matches to determine the final two CONCACAF national teams that progressed as qualifiers to the Copa América Centenario final tournament.

[1][2] Among the sixteen teams participating in the Copa América Centenario, six of them were from CONCACAF.

Four of the six CONCACAF representative teams had already qualified prior to the 2015 CONCACAF Gold Cup: The two remaining places were determined by a play-off system which itself was determined by the outcome of the 2015 Gold Cup.

Note: Per statistical convention in football, matches decided in extra time are counted as wins and losses, while matches decided by penalty shoot-out are counted as draws.

The four teams were seeded based on the Gold Cup results: The match-ups in the play-offs were: It was reported that each tie would be played over two legs in October 2015.