The 2012 Copa Sudamericana de Clubes (officially the 2012 Copa Bridgestone Sudamericana de Clubes for sponsorship reasons) was the 11th edition of the Copa Sudamericana, South America's secondary international club football tournament organized by CONMEBOL.

The draw mechanism was as follows:[3] All dates listed are Wednesdays, but matches may be played on the day before (Tuesdays) and after (Thursdays) as well.

; the defending champion, Universidad de Chile, was assigned the 10 seed).

If the teams were tied on points and goal difference at the end of regulation in the second leg, the away goals rule would not be applied and 30 minutes of extra time would be played.

If still tied after extra time, the title would be decided by penalty shootout.