In one route of preparation, an excess of acetylsalicylic acid is dissolved in aqueous sodium carbonate.

The resulting solution is then filtered to remove any undissolved acetylsalicylic acid and is mixed with a solution containing Cu2+ cations (copper(II) sulfate is suitable), precipitating bright blue crystals of copper aspirinate immediately.

Copper aspirinate has been proven effective as a treatment for rheumatoid arthritis.

[2] A pharmacokinetic study in healthy human volunteers supports its enhanced efficacy as compared with aspirin.

[3] The studies on animal models suggest that copper aspirinate is very promising in treating against thrombotic diseases and it has all the prospects of success in becoming an antithrombotic drug that prevents and treats thrombotic diseases in humans.