Coprinopsis cinerea

Rea (1922) Coprinus delicatulus Apinis (1965) Hormographiella aspergillata Guarro, Gené & De Vroey (1992) Coprinopsis cinerea is a species of mushroom in the family Psathyrellaceae.

[2] Coprinopsis cinerea is an important model organism for studying fungal sex and mating types, mushroom development,[3] and the evolution of multicellularity of fungi.

[4] It is considered to be particularly suited organism to study meiosis, due to its synchronous meiotic development and prolonged prophase.

Coprinopsis cinerea can be grown on complex (e.g. YMG, YMG/T) or minimal media (e.g. mKjalke medium), solid or liquid, with or without agitation, at 25 °C or optimally at 37 °C.

[7][8] Otherwise, insertion of integrative vectors ectopically and with small homologous regions can be used, likely with low transformation efficiency.

Earlier, REMI (restriction enzyme-mediated integration) could be used to insert exogenous DNA into the chromosome to produce mutant strains.

[11] It was recently found that a TET (Ten-Eleven translocation dioxygenases) homologue, CcTET, was identified in C. cinerea, which may have important human (or mammalian) implications like cancer.

[citation needed] Burns et al.[14] studied the expression of genes involved in the 15-hour meiotic process encompassing time points prior to the haploid nuclear fusion that forms the diploid zygote to the final formation of the four haploid products.

However, the organism can cause opportunistic infections (mycoses) in immunocompromised patients, such as those who have undergone haematopoietic stem cell transplantation or are otherwise undergoing immunosuppression treatment.

[16] Whilst exceptionally rare, Coprinopsis cinerea infection is difficult to treat and often fatal in this vulnerable patient group.

The infection is caused by the mould-like asexual (non mushroom-forming) anamorph of Coprinopsis cinerea which used to be known as Hormographiella aspergillata, and may be described under this name in the clinical literature.