It is compatible with Mac OS X 10.4 and higher; Mac OS X 10.3 needs QuickTime 7 to be installed.
[1] Core Audio Format (.caf) is designed to overcome limitations of older digital audio formats, including AIFF and WAV.
Like the RF64, it is not limited to a 4 GB file size and a single .caf file can theoretically save hundreds of years of recorded audio due to its use of 64-bit file offsets.
[2] GarageBand, Soundtrack Pro, and Logic Studio use the .caf format for their loop and sound effects library, particularly for surround-sound audio compressed with the Apple Lossless (ALAC) codec.
It is also what is used to send Audio Messages over iMessage on iOS and macOS.