He was an aspiring actor when guitarist Vernon Reid drafted him into Living Colour in 1985, reportedly after seeing Glover singing "Happy Birthday" at a friend's party.

Francis in Oliver Stone's Vietnam War film, Platoon, and starred in a short-lived television series called Signs of Life.

After the split, Glover started a solo career as Reverend Daddy Love and formed the band Vice with guitarist Mike Ciro.

In 1995, Glover participated with an ensemble of notable vocalists, guitarists, bassists, and drummers, including the London Metropolitan Orchestra, to record a Jimi Hendrix tribute album named In From The Storm.

In August 2006, Glover began co-headlining a national tour of Jesus Christ Superstar, playing the role of Judas Iscariot opposite Ted Neeley.

[8] He took the place of singer Carl Anderson, who had played Judas since 1971 alongside Neeley and was set to reprise the role, but had died of leukemia in 2004.

"[14] In 2018 Glover teamed up with guitarist George Lynch, drummer Chris Moore, and bassist Pancho Tomaselli to form the rock group Ultraphonix.