Formed in 1994[2] as an octet (under the name Galactic Prophylactic) and including singer Chris Lane and guitarist Rob Gowen, the group was soon pared down to a sextet of: guitarist Jeff Raines, bassist Robert Mercurio, drummer Stanton Moore, Hammond organist Rich Vogel, Theryl DeClouet on vocals, and later adding saxophonist Ben Ellman.
The group was started when Raines and Mercurio, childhood friends from affluent Chevy Chase, Maryland, moved to New Orleans together to attend college at Tulane and Loyola Universities,[3] became enamored of the local funk scene, populated by such legendary acts as The Meters and Dirty Dozen Brass Band and inspired by local legends such as Professor Longhair.
There they teamed with noted New Orleans drummer Stanton Moore,[3] saxophonist/harmonica (now producer) Ben Ellman, Rich Vogel, and Theryl de Clouet.
In 2004, the band parted ways with vocalist DeClouet, and continued as an instrumental group until 2007 when they released From the Corner to the Block featuring rappers ranging from Juvenile, Chali 2na, Boots Riley, and Lyrics Born.
Many of their songs include performances by other artists of various styles of music, like hip-hop artists Boots Riley (of The Coup), Gift of Gab (of Blackalicious) and Chali 2na (of Jurassic 5), to vocalists Macy Gray, Mavis Staples, Allen Toussaint, Irma Thomas, David Shaw, Mystikal, Mannie Fresh, and JJ Grey & Mofro.
The band's sound has evolved from organic New Orleans funk to a more modern style, incorporating elements of hip hop, electronica, fusion, and jazz.
The band has long considered the legendary New Orleans music venue Tipitina's an unofficial home base, having recorded a live album there, and having performed there regularly since the beginning of their career.
These include: the Soul Rebels Brass Band, The Neville Brothers, Brian Seeger, Corey "Boe Money" Henry, George Porter of The Meters, Dirty Dozen Brass Band and Skerik (a saxophone player who is actually based in Seattle, Washington, but is part of Stanton Moore's side project Garage A Trois).
King, Mike Doughty (formerly of Soul Coughing), Gift of Gab (of Blackalicious), Jurassic 5, Jack Johnson, Gov't Mule, The Revivalists, The Record Company, Trombone Shorty and Orleans Ave, Toots and the Maytals, and Steel Pulse.
Long-established performers such as Rebirth Brass Band, Irma Thomas, Big Chief Bo Dollis of The Wild Magnolias, Allen Toussaint and Walter "Wolfman" Washington are represented, along with younger performers in the traditional vein, such as Trombone Shorty and Corey Henry, John Boutté, Josh Cohen and Ryan Scully of Morning 40 Federation, and Glen David Andrews, and also Bounce artists Cheeky Blakk, Big Freedia, Katey Red, and Sissy Nobby.