[2] CR 850 begins at US Highway 41 (US 41, Tamiami Trail) in Estero, just across from the Koreshan State Historic Site, and heads east.

While not part of CR 850, Corkscrew Road does extend a half mile (0.8 km) west of US 41 as a city street accessing a residential neighborhood and the Koreshan State Historic Site.

A half a mile (0.8 km) later, CR 850 turns north-northeast and comes to an interchange with Interstate 75 (I-75).

CR 850 turns back east near the Bella Terra neighborhood, where it is reduced to a two-lane road.

It runs northeast along the north side of Corkscrew Regional Ecosystem Watershed (CREW) before coming to its eastern terminus at State Road 82 (SR 82) near Immokalee.