It continues east along the northern boundaries of San Carlos Park and Three Oaks before coming to an interchange with Interstate 75 (I-75).

Just east of I-75, Alico Road passes Gulf Coast Town Center and then intersects with CR 885 (Ben Hill Griffin Parkway), which provides access to Florida Gulf Coast University to the south and Southwest Florida International Airport to the north.

Beyond CR 885, Alico Road is reduced to four lanes as it travels along the south side of Southwest Florida International Airport.

In 2005, LCDOT completed widening Alico Road to six lanes from just east of the Seminole Gulf Railway main line crossing to Three Oaks Parkway (CR 881).

[11] In 2008, FDOT realigned Alico Road from the railroad tracks to US 41, moving its intersection with US 41 north a quarter of a mile (0.4 km).

[12] A two-mile (3.2 km) stretch of Alico Road east of Ben Hill Griffin Parkway was widened to four lanes in 2021 due to residential development.