Spaendonck initially worked under artist Guillaume-Jacques Herreyns (1743–1827) in Antwerp, and in 1773 moved to Paris to study and work with his brother, floral painter Gérard van Spaendonck (1746–1822).
From 1785 to 1800, Cornelis van Spaendonck was head of the porcelain works at Sèvres.
Due to difficulties encountered as an administrator, he was relieved of his directorship in 1800, but remained at Sèvres as a designer and artist until 1808.
[1] In 1789 Spaendonck became a member of the Académie des Beaux Arts.
Most of Spaendonck's works were created with oils and gouache, and he is remembered for his lush still-lifes of flowers.