Cornelius V. Clickener (1819 – February 17, 1864) was an American Democratic Party politician who was the first Mayor of Hoboken, serving from 1855 to 1857.

He had a business in Manhattan, New York City, which in 1852 obtained the rights to sell "Dalley's magical pain extractor", a medicated ointment.

[2][3] Clickener served as director of the Columbia Fire Insurance Company in New York City.

[6] In 1856, Clickener was appointed as Bank Commissioner for the State of New Jersey by Governor Rodman M.

A Democrat, he served as a member of the New Jersey Senate from Hudson County from 1857 to 1859.