RegionsAir operated under a code-sharing agreement with TWA and American Airlines to provide flights to communities as AmericanConnection from Lambert-St. Louis International Airport, and as Continental Connection from Cleveland Hopkins International Airport.

When TWA merged into American Airlines on December 2, 2001, Corporate began operating as AmericanConnection continuing to provide flights to communities from Lambert-St. Louis International Airport.

[3] On October 7, 2005, Viva International, an aviation holding company, issued an irrevocable Letter of Intent to Purchase RegionsAir for an undisclosed sum, but nothing ever became of the LOI.

The National Transportation Safety Board (NTSB) has determined pilot error to be the cause of this accident.

[7][8] On March 8, 2007, at 4:36pm the FAA again grounded RegionsAir due to discrepancies in the airline's training procedures for line-check airmen.