Cortical pseudolaminar necrosis

It is seen in the context of cerebral hypoxic-ischemic insults, e.g. status epilepticus, strokes.

Damage is greater in the sulci when compared to gyri of the brain.

[2] When seen on CT scan, it shows hyperdensity in the surface of the cortex.

[2] On MRI scans, early changes show low T1 intensity due to ischemic changes.

There is high T1 intensity due to accumulation of neuronal damage, reactive tissue changes, and deposition of fat-laden macrophages.

Micrograph showing cortical pseudolaminar necrosis. H&E-LFB stain .