[3] In a match against Ceahlăul on 17 October 2009, Pantilimon captained the team for the first time, since Dan Alexa, Gigel Bucur and Arman Karamyan and his brother Artavazd were all on the bench.

[5] Pantilimon was part of the Timișoara team that defeated UEFA Cup winners Shakhtar Donetsk in the qualifying rounds of the 2009–10 Champions League campaign.

[6][7] On 11 August 2011, Pantilimon joined Manchester City on a one-year loan deal from Politehnica Timișoara to act as cover for Joe Hart following the departure of Shay Given.

[10] During the 2012–13 FA Cup, he kept four clean sheets in a row and managed an outstanding performance against Chelsea in the semi-final, conceding just one goal in five matches.

In response to this performance, then City manager Roberto Mancini immediately promised that the Romanian would keep his place when the team return to Wembley Stadium to face Wigan Athletic on 11 May.

[12] It was later revealed that Mancini had promised on the eve of the FA Cup Final that the Romanian would play, but then deputed the goalkeeping coach on match day morning to say there had been a change of plan.

[15] Five weeks later, Pantilimon was also selected to start in the next League Cup match away to Newcastle United on 30 October; once again, he conceded no goals, as City won 2–0 and progressed to the last eight of the competition.

[16] Three days later, he made his Premier League debut at home to Norwich City, keeping his third clean sheet in a row in an emphatic 7–0 victory.

[28] On 31 January 2018, Pantilimon left Spain to return to England and sign on loan for EFL Championship side Nottingham Forest until the end of the 2017–18 season.

[31] He made the English Football League's Team of the Week after producing a clean sheet at Burton Albion when Forest were reduced to ten men for much of the match on 17 February.

[34] On 4 September 2020, Pantilimon joined Turkish Süper Lig side Denizlispor following a mutual termination of his contract at Nottingham Forest.

[36] On 31 May 2016, Pantilimon was included in the final 23-man squad for UEFA Euro 2016, but did not appear in all matches in this tournament; Romanian coach Anghel Iordănescu used Ciprian Tătărușanu as the nation's first-choice.