Francis Louis of Palatinate-Neuburg (Franz Ludwig von Pfalz-Neuburg; 18 July 1664 – 6 April 1732) was bishop and archbishop of several dioceses, prince-elector of the Holy Roman Empire, and Hochmeister of the Teutonic Order.

He was born in Neuburg an der Donau as son of Philip William, Elector Palatine and Landgravine Elisabeth Amalie of Hesse-Darmstadt.

In 1683, he became Prince-Bishop of Breslau (Wrocław) after the death of his brother Wolfgang Georg, who should have held this office.

During his rule in Trier, he reorganized the jurisdiction in the diocese and advanced the renovation of the Roman Moselle bridge and the cathedral.

In Mainz, Franz Ludwig also started some administrative and judicial reforms as well as the construction of the Deutschhaus.