SR 426 is signed east–west, but takes a diagonal path through the Orlando-Kissimmee, Florida, Metropolitan Statistical Area and rural Seminole County, by the Econlockhatchee River.

At the corner of SR 426 and Denning Drive, a sinkhole comes in sight, however, it was turned into a man-made lake.

Briefly passing through Goldenrod and the beginning of SR 551 it finally enters Seminole County and heads NNE.

Now leaving the Orlando-Kissimmee, Florida, Metropolitan Statistical Area and the City of Oviedo, it runs along the Econlockhatchee River for a short time.

202, beginning at the East City limits of Winter Park, in Orange County, through Winter Park and on Fairbanks Avenue to the old Apopka Brick Road, thence northwesterly crossing the Seaboard Air Line Railroad, turning left and intersecting State Road No.

2, thence Westerly through Clarcona intersecting Apopka-Ocoee Road one-quarter mile South of Atlantic Coast Line Railroad."