Originally the main thouroughfare connecting the major cities of Central Florida, this has since been superseded by Interstate 4 (I-4), which runs nearly the same route.

After crossing the Gandy Bridge, US 92 intersects West Shore Boulevard and runs east along Gandy Boulevard until it reaches Dale Mabry Highway at the first interchange with the Lee Roy Selmon Expressway where it turns north.

Within Plant City US 92 approaches the southern terminus of SR 566 (Thonotosassa Road) then splits into a one-way pair.

In downtown Plant City, US 92 encounters SR 39A, with which it has a two-block overlap between Wheeler and Collins Streets.

After the one-way pair ends, the last state highway to intersect the route in the city and Hillsborough County is the southern terminus of SR 533 (Park Road).

East of SR 533, the road encounters a random series of level crossings for freight spurs leading from the CSX Lakeland Subdivision.

It also passes by a former truck weigh station, and then runs beneath SR 570 (Polk Parkway) with no direct access.

US 92/SR 546 continues eastbound along Memorial Boulevard where it climbs a bridge over the CSX Vitis Subdivision and SR 539 with no access.

Across from the south side of Auburndale Cemetery the western terminus of SR 544 branches off to the southeast towards Legoland (formerly Cypress Gardens) and part of Haines City.

It enters downtown Haines City on Hinson Avenue after crossing under US 27 at a cloverleaf, meeting the northern end of SR 17 (formerly US 27 Alt.)

The OBT name temporarily ends at Pleasant Hill Road (former SR 531) in southern Kissimmee, where US 92 uses John Young Parkway (formerly Bermuda Avenue) to Vine Street (US 192/SR 530).

Along this stretch, the road intersects the Osceola Parkway in Kissimmee, SR 417 (Central Florida GreeneWay) at exit 11, and the Central Florida Parkway as it passes east of the resort area of Orlando that includes Walt Disney World and affiliated resorts, Sea World, and Universal Studios.

OBT then comes to a massive combined interchange with Florida's Turnpike and SR 528 (Beachline Expressway) in Sky Lake.

It crosses Lake Estelle on the Andrews Causeway before reaching the border between Orlando and Winter Park.

To the west of the split, International Speedway Boulevard is CR 92, a short connection to SR 15A that allows traffic on US 92 to bypass downtown DeLand.

From DeLand to its terminus in Daytona Beach, US 92 carries the local name, International Speedway Boulevard, running through Tiger Bay State Forest then passing a connecting road towards I-4 with a westbound only flyover off-ramp and an eastbound only on-ramp from exit 129.

The highway serves as the southern terminus of LPGA Boulevard then has an interchange with I-95 before it passes by the Daytona International Speedway.

US 92 spans the Halifax River and Intracoastal Waterway via the Broadway Bridge before reaching its eastern terminus at SR A1A.

US 92 was signed along the following roads in 1927: When the bypass of downtown Tampa on SR 17 (Hillsborough Avenue) opened in the early 1930s, US 92 and US 41 were rerouted to use it.

In 1947, the route was extended east in Daytona Beach across the Intracoastal Waterway and the Halifax River after the Broadway Bridge was reconstructed and opened.

In late 2013, FDOT began an $80 million project to construct a flyover interchange with US 17/US 92 traveling over SR 436 in Casselberry.

Sloan Avenue becomes a divided highway between the 12-foot-6-inch (3.81 m) bridge beneath the CSX Lakeland Subdivision, only to emerge at the intersection of West Main Street where it turns east.

The road makes a brief left turn onto Massachusetts Avenue in front of Lake Mirror for one block, then turns right at the end of Cedar Street where it runs along the north shore of Lake Mirror passing by Lakeland Amtrak Station.

From there it has an intersection with US 98 (SR 548), and after Lake Parker Avenue makes a north turn onto Tyler Road.

The road crosses under the CSX Carters Subdivision, this time beneath a 13-foot-6-inch (4.11 m) two-lane undivided bridge, and then curves onto East Gary Road, where it runs east until finally ending at US 92 along the south shore of Lake Parker.