The route enters Woolwich Township and forks to the left onto Swedesboro Road, passing over the New Jersey Turnpike.

The road continues into a mix of farmland and woodland, intersecting CR 614 before crossing into South Harrison Township.

Past this junction, the route enters more forested areas of residential subdivisions with a few farms, crossing CR 581.

The road continues into Elk Township and reaches the Route 77 junction.

From here, CR 538 turns more southeast and continues through farmland and woodland with a few residences, entering Franklin Township and becoming Swedesboro Road.