A bypass of Mullica Hill was completed in 2012 for US 322 in order to relieve traffic through that town; the former alignment is now unsigned US 322 Business (US 322 Bus.).

[1] It passes over Conrail Shared Assets Operations' (CSAO) Penns Grove Secondary and continues through rural areas of farms and woods prior to an interchange with Interstate 295, at which point the road widens into a four-lane divided highway.

At the end of the bypass, the route intersects US 322 Bus./CR 536 again and turns east onto Mullica Hill Road, again becoming concurrent with CR 536.

[1] At the interchange, US 322 is briefly a four-lane road, and passes north of Inspira Medical Center Mullica Hill before entering Glassboro.

[1] Here, it turns south to form a concurrency with that route on three-lane Delsea Drive, passing more homes and businesses.

US 322 splits from Route 47 by heading east on High Street, a two-lane road, and enters wooded areas with some development and farmland.

[1][3] After exiting Glassboro for Monroe Township, US 322 continues east and crosses County Route 555 prior to reaching Williamstown, where the road passes residential and business development.

[6] Entering Folsom in Atlantic County, US 322 passes a couple lakes and some wooded residences before coming to a bridge over the Beesleys Point Secondary railroad line operated by the Cape May Seashore Lines railroad before an interchange with Route 54, where the route has a median.

[1][3] After this intersection, US 322 turns south and enters Hamilton Township, where it encounters County Route 559 at a traffic circle that has been modified to have US 322 run through it.

[1] After passing more woods and a clearing for farms, the road widens into a four-lane divided highway and has an interchange with Route 50.

A short while after, the route enters a residential and commercial area, passing by Atlantic Cape Community College before heading to the south of the Hamilton Mall.

US 40/US 322 forms a concurrency with that route and passes through a business district that includes the Harbor Square shopping center.

CR 563 splits from the road by continuing southeast and the Black Horse Pike heads east to an interchange with the Garden State Parkway.

[3][7] The only direct ramp present is between the Black Horse Pike westbound and the Garden State Parkway northbound, with all other movements provided by CR 563.

Here, the name becomes Albany Avenue and it comes to a pair of ramps that provide access to and from the Black Horse Pike eastbound and the Atlantic City Expressway westbound.

Past this bridge, the road passes between businesses to the west and the closed Bader Field airport and Surf Stadium to the east.

[24] The freeway, which was planned to connect the then-proposed Commodore Barry Bridge to Route 42 in Williamstown, was projected to cost $59.6 million.

[30] In December 2008, jurisdiction of US 322 from the Woolwich–Harrison township line to the Route 55 interchange and a 0.35-mile-long (0.56 km) segment within Glassboro was transferred from the state highway agency, the New Jersey Department of Transportation, to Gloucester County.

[1][20] Construction of a bypass around Mullica Hill began in December 2010 in order to relieve severe traffic congestion through the town.

[31] The road was estimated to cost $12 million,[32] and is described by a freeholder as being the "largest infrastructure project that has ever been undertaken in Gloucester County.