West Virginia Route 891 is a 2.29-mile (3.69 km) long east–west state highway located in Marshall County, West Virginia.

The eastern terminus is at the Pennsylvania state line, where WV 891 continues east as Pennsylvania Route 21.

WV 891 begins at an intersection with US 250 north of Cameron and heads east.

The very curvy route mainly serves as a connector to Pennsylvania Route 21, as the highway intersects no other state highways and doesn't run through any communities.

The entire route is in Marshall County.