[2][3] The portion of the road in Roslyn Heights is honorably named Langone Brothers Avenue, after two local firefighters killed on September 11, 2001.

[2][3] It travels north-northwest underneath the Long Island Rail Road's Main Line and Oyster Bay Branch, then intersecting Second Street (CR E23) shortly thereafter.

From there, CR E64 continues north through Williston Park, passing and crossing the former route of the Long Island Motor Parkway before entering Albertson.

It then continues north and north-northeast through Albertson, eventually reaching and crossing underneath the Northern State Parkway; Willis Avenue enters Roslyn Heights at this location.

The road then enters the Incorporated Village of Flower Hill, continuing north to Northern Boulevard (NY 25A), where the county route designation terminates.

[14][15][16] As part of the reconstruction project, Willis Avenue was lowered in the area to run underneath the tracks, thus eliminating the two grade crossings, which frequently caused congestion and safety hazards along that portion of the road.

[14] The elimination of Willis Avenue's two grade crossings – along with others in Mineola – had been proposed by New York State for decades, but had been pushed back and stalled due to community opposition and cost overruns.