Courtois Creek (locally /ˈkoʊtəweɪ/) is a 38.6-mile-long (62.1 km)[7] stream in southern Missouri, United States.

The stream enters the southwest corner of Washington County, flows past Courtois and on north through the Mark Twain National Forest, entering Crawford County just south of Berryman and passing under Missouri Route 8 just west of that village.

It flows on northwest through the Missouri Ozarks of Crawford County, roughly paralleling the course of Huzzah Creek to its west.

It flows into Huzzah Creek just before the latter's confluence with the Meramec River, near the Crawford County Highway E bridge just east of Scotia.

It is surrounded by dense stands of trees and native vegetation, has abundant fish, turtles and waterfowl, and is the best-protected stream in the area against erosion.