The song's lyrics describe the sexual desires the narrator, Dupree, has for his attractive cousin Janine.
In 2001, the song won a Grammy Award for Best Pop Performance by a Duo or Group with Vocal.
In July 2006, Steely Dan posted a humorous letter on their website saying that the title of Owen Wilson's film You, Me and Dupree was stolen from their song.
[1] The film is about a house guest who overstays his welcome; the song's title character is a slacker who is sleeping on his aunt's couch.
Owen Wilson defended himself in similarly deadpan comic fashion, stating, "I have never heard the song 'Cousin Dupree' and I don't even know who this gentleman, Mr. Steely Dan, is.