Cozzene (May 8, 1980 – October 7, 2008) was an American Champion Thoroughbred racehorse and outstanding sire.
At age four he won three more races from ten starts and ran third in the Breeders' Cup Mile.
The previous year, in the inaugural running of the Breeders' Cup Mile at Hollywood Park Racetrack, Cozzene had finished third but came back to win the November 2, 1985 edition at Aqueduct Racetrack .
His 1985 performances earned him the 1985 Eclipse Award for American Champion Male Turf Horse.
The stallion had had melanoma, a disease many gray horses get, for years but it had not caused him any pain until recently.