Crézancy-en-Sancerre (French pronunciation: [kʁezɑ̃si ɑ̃ sɑ̃sɛʁ]) is a commune in the Cher department in the Centre-Val de Loire region of France.

A farming and winegrowing village situated some 22 miles (35 km) northeast of Bourges at the junction of the D22 with the D86 roads.

The commune is one of only a few that grow grapes for Sancerre AOC wines.