Crabtree Creek is a tributary of the Neuse River in central Wake County, North Carolina, United States.

Today, the Lassiter Mill site is a Raleigh City park, part of the greenway system, and is open to the public.

Construction of lakes on the creek and its tributaries to control floods have only partially alleviated this problem because rapid development of Wake County has greatly increased storm runoff.

In fact, the new channel of the creek at the mall has proved to be inadequate for peak flows.

The United States Geological Survey has a monitoring station on Crabtree Creek at highway 70 in Raleigh.

The city is planning a "west extension" (which will extend the 14.6 miles) to Umstead State Park.