Coles Branch is a 2.7 mi (4.3 km) long tributary to Crabtree Creek in Wake County, North Carolina, and is classed as a 2nd order stream on the EPA waters GeoViewer site.

[4] Coles Branch rises in a pond in western Cary, North Carolina, and then flows northwest to Crabtree Creek.

[4] Coles Branch drains 2.60 square miles (6.7 km2) of area in the western part of Cary.

Coles Branch is underlaid by the Deep River Basin.

[5] The watershed receives an average of 46.4 inches (118 cm) per year of precipitation and has a wetness index of 413.95.