[3][9] After winning a runoff election on April 13, 2010, by a margin of 42 votes (which held through an automatic recount)[4] Lowe became mayor-elect of Gainesville.

He lost his bid for re-election on April 16, 2013, to former City Commissioner Ed Braddy after being arrested for a DUI during the campaign.

Lowe also served as Chair of the Gainesville City Commission’s Equal Opportunity Committee, a member of the Regional Utilities, Community Development, and Countywide Visioning & Planning committees as well as the local Community Redevelopment Agency, the Gainesville/Alachua County Metropolitan Transportation Planning Organization and the Alachua County Library Governing Board.

[15] Prior to the runoff election on April 16, 2013, Lowe was arrested on suspicion of driving under the influence (DUI).

[22] On April 1, 2013, Lowe entered into a deferred prosecution agreement aimed at first-time DUI offenders to resolve the charges against him.