Crassispira kluthi is a species of sea snail, a marine gastropod mollusk in the family Pseudomelatomidae.

A row of small tubercles ascends the spire, scarcely discernible on the last whorl, which (as in Crassispira rudis) descends and rises again at the aperture, making the spire-outlines curvilinear.

The surface shows extremely fine lines of growth, faintly decussated by spiral striae.

The spire is generally incrusted with blackish mud, sometimes bearing round flat egg-cases, pierced in the middle.

[2] This species occurs in the Pacific Ocean off Panama; fossils were found in Pleistocene strata of the Gulf of California.