She began her career as a child actress playing one of the lead characters, Babe, in the Nickelodeon comedy television series Game Shakers, which aired from 2015 to 2019.

[2] Cicchino started dancing at age 4,[5][6] but her mother put her in acting classes at 11 or 12 years old after which she decided she wanted to be an actress.

[4][7] In 2015, at age 13, Cicchino was cast in leading role of Babe in the Nickelodeon television comedy series Game Shakers,[8][9] which ran for three seasons.

[11][12] In July 2021, she was cast as Luisa Torres in the HBO Max limited television series And Just Like That..., based on Sex and the City.

She is credited by only her first name in the film, having revealed her decision to continue her career mononymously as Cree in a Zach Sang podcast the week before its release.