Originally built in Romanesque style, the cathedral has been restored and extended several times, with Gothic, Renaissance and Baroque elements.
The oldest are the frescoes of the Stories of Abraham, Isaac, Jacob and Joseph in the southern and northern transept vaults (late 14th-early 15th century).
The wooden choir, with inlay work by Platina (1482-1490), and the contemporary large altar cross in silver and gold, by Ambrogio Pozzi and Agostino Sacchi (1478), in the right aisle of the northern transept, are also notable.
The most important figurative complex of the cathedral is the fresco decoration on the side walls of the nave (early 16th century), portraying the Life of Mary and Christ.
Different painters collaborated to its execution: the first was Boccaccio Boccaccino (with Annunciation to Joachim and Jesus with the Doctors), who, in 1506, had already painted a Redemeer with Cremona's Patron Saints in the apse vault.
He was succeeded by Giovan Francesco Bembo (Epiphany and Presentation at the Temple) and Altobello Melone (Flight to Egypt, Massacre of the Innocents and the first four panels of the Passion of Christ), who both adopted a less classicist style.
The last scenes of the Passion were executed by Il Pordenone, who was also responsible of the large Crucifixion (1521), the Deposition (1521, counterfaçade) and the Schizzi Altarpiece (before 1523, on the first altar in the right aisles), the latter inspired by Giorgione's style.