In addition to the CB&Q mainline, two branch lines originated from here, and another railroad operated from the depot as well.

[5]: 91 With passenger rail service in the United States declining rapidly in the 1960s, the large Creston station was deemed too expensive to maintain.

In 1969, the CB&Q built a small brick and steel depot to the east of the original station which was later used by Amtrak after its creation in 1971.

[5]: 91 In 1970, Creston's mayor noted that the station would be a good site for a parking lot.

Following $1.3 million in improvements including making its waiting room accessible, Amtrak relocated to it on August 1, 2019; the nearby platforms of the 1969 station remain in use.