As of November 2024[update], Endeavour holds the single-mission record for the most time in orbit by an American crewed spacecraft at 235 days.

[7] NASA's Aerospace Safety Advisory Panel (ASAP), on 23 April 2024, gave its approval for the late May launch saying it was feasible and safe.

[8] Endeavour was transported to the Kennedy Space Center, arriving at SpaceX's horizontal integration facility (HIF) at Launch Complex 39A on 15 May 2020.

[11] Their mission validated crewed spaceflight operations using SpaceX hardware, including the Dragon spacecraft, the Falcon 9 rocket.

[17][18][19] Hurley and Behnken joined the ISS Expedition 63 crew, which consisted of NASA astronaut Chris Cassidy and Russian cosmonauts Ivan Vagner and Anatoli Ivanishin.

[20] Behnken and Hurley launched to the ISS for an indeterminate time frame, which depended on Endeavour's solar array degradation, the status of Crew Dragon Resilience, and landing zone weather.

[21] NASA originally planned Demo-2 as a short test flight lasting about two weeks, but later chose to extend the mission to address the shortfall of crew in the ISS.

[21] When Endeavour returned on 2 August 2020, it journeyed through a fast fiery descent of Earth's atmosphere and was slowed down by the capsule's drogue chute and suite of parachutes.

[23] It splashed down in the Gulf of Mexico, near Pensacola, Florida, where a SpaceX recovery ship Go Navigator brought the crew and spacecraft back to shore.

[32][34] Weather in the landing zones, including Hurricane Milton, then caused further delays, but the crew finally splashed down off of the coast of Pensacola, Florida on 25 October 2024.