It first launched on 16 November 2020 to the International Space Station (ISS) on the SpaceX Crew-1 mission, the first operational flight of NASA's Commercial Crew Program.

[3][4] At a NASA press conference on 29 September 2020, commander Michael Hopkins revealed that C207 had been named Resilience.

[6] Resilience was first launched on 16 November 2020 (UTC) on a Falcon 9 from the Kennedy Space Center (KSC), LC-39A, carrying NASA astronauts Michael Hopkins, Victor Glover, and Shannon Walker, and JAXA astronaut Soichi Noguchi on a six-month mission to the International Space Station.

[8] For Polaris Dawn mission, as Crew Dragon capsules lack an airlock, several modifications have been made to the interior of Resilience.

To validate their procedures, Resilience underwent multiple cycles of venting and repressurization in a large vacuum chamber.