Crewe and Nantwich is a constituency in Cheshire represented in the House of Commons of the UK Parliament.

The seat is marginal as Crewe tends to vote Labour, and Nantwich and the surrounding Cheshire villages are more Conservative-inclined.

She died on 17 April 2008, after 34 years representing the seat and its predecessor, leading to a by-election held on 22 May 2008 which was won by the Conservative candidate Edward Timpson.

Having previously enjoyed a considerable lead in support over the Conservatives (as indicated in Gwyneth Dunwoody's over 7,000 majority in 2005), the Labour government had lost support due to the onset of the Great Recession and Gordon Brown’s relatively weak image as a leader.

1983–1997: The Borough of Crewe and Nantwich wards of Acton, Alexandra, Audlem, Barony Weaver, Bunbury, Combermere, Coppenhall, Delamere, Grosvenor, Maw Green, Minshull, Peckforton, Queens Park, Ruskin Park, St Barnabas, St John's, Shavington, Waldron, Wellington, Weston Park, Willaston East, Willaston West, Wistaston, Wrenbury, and Wybunbury[8] 1997–2010: The Borough of Crewe and Nantwich wards of Alexandra, Barony Weaver, Coppenhall, Delamere, Grosvenor, Haslington, Maw Green, Queens Park, Ruskin Park, St Barnabas, St John's, Shavington, Waldron, Wellington, Weston Park, Willaston East, Willaston West, Wistaston, and Wybunbury[9] 2010–2024: The Borough of Cheshire East wards of Crewe Central, Crewe East, Crewe North, Crewe St Barnabas, Crewe South, Crewe West, Haslington, Leighton (most), Nantwich North & West, Nantwich South & Stapeley, Shavington, Willaston & Rope, Wistaston, and Wybunbury.