On 3 July 2012 he was elected President of the Senate after the dismissal of the former leader, Vasile Blaga, from office.

On 4 March 2014, during the debate in parliament on the vote for a new government, Antonescu resigned as president of the Senate.

[3] Upon graduating in 1985, Crin Antonescu worked as a History teacher in the village of Solești, Vaslui County.

In 1995, he was elected PNL Vice President and, subsequently, leader of the liberal politicians active in the Chamber of Deputies, holding that position for two non-consecutive mandates.

[6] He initiated a series of reforms, the most prominent being the legal perpetuity for Romanian athletes with significant Olympic results.