[1][2][3] Born in Cernusco sul Naviglio, the Province of Milan, Biraghi began his career with Internazionale, playing in their youth teams from 2005 onwards.

He played a few friendlies for the club[5][6][7] and participated in their 2010 summer tour,[8] scoring a goal in the Pirelli Cup, helping them to a 3–0 victory over Manchester City.

[9] Biraghi made his first team debut in a competitive game on 24 November 2010, against Twente in the 2010–11 UEFA Champions League, replacing Goran Pandev.

Biraghi would be given a starting berth in Inter's next game in the Champions League, on 7 December 2010, against Werder Bremen in what would be a 3–0 home win for the German side, with the likes of Davide Santon moving to wing forward and Cristian Chivu unable to play due to an injury.

[18] On 27 August 2015, Biraghi moved to La Liga side Granada CF, after agreeing to a one-year loan deal.

[24] Under the new regime of Ciro Ferrara, he made his U21 debut on 17 November 2010, as starting left back in the friendly match that Italy won 2–1 against Turkey.

[29] He made his senior international debut in Italy's 1–1 home draw against Poland on 7 September, in their UEFA Nations League opener.