Cristoforo Numai (died 23 March 1528) was an Italian Franciscan, who became minister general of the Friars Minor and a cardinal.

Less than a month later he was raised, in spite of his protests, to the cardinalate by Pope Leo X, who in presence of the Sacred College paid a splendid tribute to Christopher's great learning and prudence and to his still greater holiness of life.

During the Sack of Rome (1527) by the soldiers of the Duke of Bourbon, Christopher suffered many hardships and insults, on account of which he received letters of condolence from Pope Clement VII, Francis I of France, and Henry VIII of England.

His remains were transferred back from Ancona to Rome, and placed in the Church of Ara Coeli.

Besides an Exhortatio ad Galliarum regem Franciscum I in Turcas and a number of letters addressed to that king and the other rulers concerning the liberation of Clement VII, Christopher is said by Luke Wadding and others to have written several treatises on theological and ascetical questions, all of which appear to have perished during the sacking of Rome.