Cross Island National Wildlife Refuge is a National Wildlife Refuge in the state of Maine.

It is one of the five refuges that together make up the Maine Coastal Islands National Wildlife Refuge, along with Petit Manan, Franklin Island, Seal Island, and Pond Island.

Cross Island NWR has a surface area of 1,700 acres (6.9 km2).

Cross Island National Wildlife Refuge consists of six islands: This article incorporates public domain material from websites or documents of the United States Fish and Wildlife Service.

This article related to a protected area in Maine is a stub.